Best Friends is nationwide animal rescue and advocacy organization, with spay neuter, TNR (trap neuter return), pet adoption and no-kill programs.Best Friends LA · Best Friends Store · Best Friends National · Dogs. Adopt a dog. Browse adoptable dogs and puppies from Best Friends. We have purebred, mixed breed, big, small, playful, relaxed, and all ages available. Best Friends is a no kill animal sanctuary. Learn more about our no-kill philosophy and outreach programs (spay neuter, TNR, etc.) around the country.